About Isopathy

Updated: May 31, 2019

Pleomorphic remedies (also known as Isopathy / Sanum Remedies) are a form of oral therapy. In Isopathy, there is a fundamental mutability of form of microorganisms; that rests on the belief in the fundamental mutability of form in microorganisms and that microorganisms can abruptly change from an avirulent benign form into a potentially virulent, pathogenic form. Pleomorphism proposes that an endobiont (symbiotic, primal plant germ in the erythrocyte, as named by Professor Dr. Gunther Enderlein) lives in genuine symbiosis with the host organism (the patient) with mutual benefits. Only through outer factors can the endobiont multiply and develop in a process which can considerably disturb the symbiotic equilibrium and cause dysfunction in the body.

Simply stated, Pleomorphism is based on the theory that every warm-blooded organism houses a primal plant germ which can change in form through environmental influences. Whereas allopathic medicine (western medicine) rests on monomorphism which assigns only a single form and function to microorganisms and does not recognize cyclical developmental changes.

A lesser known discipline formulated by Johann Joseph Wilhelm Lux in the 1830’s, Isopathy is essentially a more specific subversion of homeopathy. Rather than “like cures like”, isopathy uses “exactly the same thing cures the thing.” Isopathic remedies are made from the actual cause of the illness or from its byproducts, and are not directed against the disease or its symptoms, but instead support the body’s own capabilities for regeneration, whereby genuine healing processes become possible.

Gunther Enderlein (1872-1968) is often called the founder of  Isopathic Medicine, though the work of Johan Joseph Wilhelm Lux and  Antoine Bechamp precedes it. Enderlein was a German zoologist and  entomologist and built his research on Antoine Bechamp’s discoveries  that an unfavorable host and environmental conditions destabilize the host’s native microzymas.  Enderlein proved that blood is not sterile,  and that a microorganism can appear in various developmental stages and  in diverse forms, without the loss of its specific characteristics. He  came to the conclusion that the monomorphistic perspective of disease conditions favored by Louis Pasteur and others could no longer be  maintained and that a pleomorphic perspective more accurately reflected  the disease process.

Benefits of Isopathy / Pleomorphic Remedies

Clinical experience has shown that isopathy may be used for a number of conditions and issues, and that the benefits include:

  • Assistance in regulating internal ecology (pH and cell respiration)

  • Regulates dysfunctions of the lymphatic system

  • Supports GI system and its beneficial microflora

  • Supports the elimination of metabolic and decomposition waste

  • Reduces the effects of biochemical stressImproves immune function and microcirculation


Isopathy is based on the presence of microorganisms in the body which can change form depending on its internal environment. Isopathic/ pleomorphic therapy normalizes the symbiotic equilibrium between endobiont and species-identical organism. Isopathic remedies help in harmonizing and treating imbalances in the body, and are useful in treating various medical conditions and providing new potential treatments for illnesses.

When a disturbed symbiosis morphs into the original healthy state, this indicates the healing process is present. Whether self-healing forces of the organism supercede disease, or whether the symbiont is able to develop unchecked into a parasite, depends on the conditions of the malady.

If the inner milieu is damaged through poor nutrition, lifestyle choices disturbing the body’s acidity and equilibrium, environmental toxins, constant infections, or depression, our self-healing forces are incapable of restoring our symbiotic equilibrium.  This is when disease manifests and damages the body. Isopathy does not work against the symptoms of a disease or the disease itself. Rather, it works to regenerate the internal milieu by supporting the body. 

In 1916, Enderlein discovered that primitive microorganic forms prepared in a remedy, when combined with biological change within the body, can cause the virulent forms to return to their original avirulent condition, this bringing about healing within the host body. He found  that when the tiniest, mobile living forms of bacteria, which he called “spermits” exchanged genetic material with higher developmental organisms, the highly developed organisms became suddenly invisible,  having been broken down to their primitive avirulent forms.

Using this knowledge, he developed isopathic remedies from fungal cultures. When these living remedies contact virulent microbial masses, the masses are induced to return to their avirulent form, and then leave the body through the natural organs of elimination.

A key concept within pleomorphism is the biological terrain, or inner milieu, as described by Enderlein and Bechamp. A healthy patient with a well balanced inner environment (biological terrain) is capable of restoring equilibrium and maintaining a symbiotic relationship with endobionts. In this process, the more highly developed pathogenic germs are broken down into avirulent primitive forms through the copulation described by Enderlein. However, the capacity for regenerating symbiosis is usually massively weakened through unhealthy lifestyles. If the internal environment or milieu is cleaned up by changing diet, balancing pH, and reducing stress, the favorable forms of microorganisms are introduced to the ones that already exist, to restore the original biological terrain and microorganism base.

“ Le microbe n’est rien, le terrain est tout.” The microbe is nothing, the terrain is everything.

---- last words of Louis Pasteur, Father of the “Germ Theory” of disease


Because Enderlein wrote all his publications (more than 500) in German, his important work has until now been almost completely unknown outside German speaking countries. However, Enderlein’s research was recently summarized in English by Dr Maria-M. Bleker (Blood Examination in Darkfield, Semmelweis-Verlag, Hoya, Germany, 1993, ISBN 3-925524-01-0). It is to be hoped that the results of Enderlein’s research will now get the attention they deserve.

source: Blood examination in darkfield according to Professor Dr. Gunther Enderlein Pleomorphic remedies are able to regulate all nonspecific, general symptoms that pertain to the Endobiosis complex, based on the knowledge of the mutability of microbial forms and the fact of the biological, and essential for life symbiosis between the mammal organism and the Endobiont. The immunobiological preparations contain diverse fractions of various bacterial species, such as intact cells, cellular extracts, and cell wall fragments of polysaccharides. Isopathic remedies are capable of stepping into the course of a physical immune reaction and raising the immune system’s capacity for response through their nonspecific stimulation. This takes influencing diverse subpopulations of lymphoid and phagocytizing cells which take part in the immune functions.

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